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Humanizing the yeast telomerase template.
Saccharomyces cerevisiae contains an irregular telomere sequence (TG1-3)n, which differs from the regular repeat (TTAGGG)n found at the telomeres of higher organisms including humans. We have modified the entire 16-nt template region of the S. cerevisiae telomerase RNA gene (TLC1) to produce (TTAGGG)n repeats, the human telomere sequence. Haploid yeast strains with the tlc1-human allele are via...
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ژورنال
عنوان ژورنال: National Municipal Review
سال: 1919
ISSN: 0190-3799,1931-0250
DOI: 10.1002/ncr.4110080905